The number of pitches a pitcher can throw varies depending on the level of play, league rules, and health considerations:

• In many youth leagues, including Little League, pitch counts are strictly limited by age. For example, pitchers aged 13–16 have a daily limit of 95 pitches, while those aged 17–18 can throw up to 105 pitches per day. After reaching certain pitch thresholds, mandatory rest days are required before pitching again

• In high school baseball, such as in Connecticut's CIAC, there is a maximum limit of 110 pitches per game or day. If a pitcher reaches 110 pitches while facing a batter, they may finish pitching to that batter but must then be removed. Required rest days depend on the number of pitches thrown (e.g., 1 day for 26-50 pitches, 3 days for 76-110 pitches)

• At the professional level (MLB), starting pitchers are often removed after about 100 pitches to preserve stamina and reduce injury risk. It is rare for a starter to exceed 125 pitches in a game. Pitch count limits are less formal but are managed by teams based on pitcher health and effectiveness

• Pitch counts also serve as a measure of efficiency, with fewer pitches per inning being preferable. Teams monitor pitch counts closely, sometimes attempting to tire pitchers by increasing their pitch counts

In summary, a pitcher can throw anywhere from about 70 to 110 pitches in a game depending on league rules, with professional pitchers typically capped around 100 pitches per game. Youth leagues impose stricter limits with mandatory rest periods to protect young arms