Deion Sanders has two sons currently in the NFL on different teams:

• Shedeur Sanders, a quarterback, was drafted by the Cleveland Browns in the fifth round of the 2025 NFL Draft

• Shilo Sanders, a safety, signed as an undrafted free agent with the Tampa Bay Buccaneers shortly after the 2025 NFL Draft

So, Deion Sanders has two sons on NFL teams as of 2025.