The letters in the word "game" can be used to make a total of 16 words. Some of the words include game, mage, mega, mag, mae, gem, gam, age, em, ma, am, ag, me, and ae. These words vary in length from 2 to 4 letters, with a few anagrams of "game" such as mega and mage included. This information comes from multiple sources focusing on word unscrambling and word games, and specifically mentions that "game" leads to about 16 possible words in English word games like Scrabble and Words With Friends.