The safe maximum dosage of acetaminophen for most healthy adults is no more than 4,000 milligrams (mg) per day from all sources. However, to minimize risk to the liver, it is generally safest to stay closer to 3,000 mg per day if possible, especially with frequent use. Taking more than the recommended dose can lead to severe or even fatal liver damage. It is important to read medication labels carefully, avoid using multiple products containing acetaminophen simultaneously, and consult a doctor if you have liver disease or consume alcohol regularly, as the safe dose may be lower in those cases.

Adults should not exceed the following dosing guidelines:

• Regular strength (325 mg per pill): up to 12 pills per day (3,900 mg), ideally fewer
• Extra strength (500 mg per pill): up to 8 pills per day (4,000 mg)
• Extended release (650 mg per pill): up to 6 pills per day (3,900 mg)

Doses should be spaced out as directed, typically every 4-8 hours depending on the product, and the lowest effective dose should be used.