The recommended dosage of Benadryl (diphenhydramine) for dogs is generally about 1 mg per pound of the dog's body weight, given two to three times a day (every 8 to 12 hours). For example, a 10-pound dog would typically receive about 10 mg of Benadryl per dose. The dosage range can vary between 1 to 2 mg per pound, or equivalently 2 to 4 mg per kilogram of body weight. It is important to use only Benadryl that contains diphenhydramine as the sole active ingredient and avoid formulations with alcohol, sodium, or other additives. Benadryl is usually administered in tablet or liquid form, with dosage amounts adjusted based on the dog's weight and the concentration of the medicine. Side effects may include drowsiness, dry mouth, urinary retention, or gastrointestinal issues. Care should be taken to avoid overdose, which can lead to severe symptoms such as agitation, seizures, or abnormal heart rate. Always consult a veterinarian before giving Benadryl to your dog to ensure the correct dosage and safety, especially if the dog has other health conditions or is on other medications.

Dosage Reference Chart (Approximate)

Dog's Weight (lbs)| Benadryl Dosage (mg)| Liquid Benadryl (12.5 mg/5 ml) Approx. (ml)
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10| 10 mg| 4 ml
20| 20 mg| 8 ml
30| 30 mg| 12 ml
40| 40 mg| 16 ml
50| 50 mg| 20 ml

Dosage can be repeated every 8 to 12 hours as needed under veterinary guidance.