The danger from Roundup exposure varies based on amount, frequency, and method (skin contact, inhalation, ingestion). The active ingredient, glyphosate, has an EPA chronic reference dose considered safe for long-term exposure at 1.75 mg/kg body weight per day, but even low levels are debated as potentially unsafe. Acute poisoning can occur if large amounts (e.g., ingestion above 50 mL of concentrated product) take place, leading to severe symptoms or death. Chronic or repeated exposure, especially occupational, has been linked to increased cancer risk, notably non-Hodgkin lymphoma after about 10 years of exposure. Short-term exposure can cause irritation and respiratory symptoms. Children, pregnant women, and frequent handlers are more vulnerable. Protective measures like gloves and masks are recommended to minimize risk. Overall, any exposure carries some risk, but large or prolonged exposure is the most dangerous.