The safe dosage of naproxen depends on whether it is taken over-the-counter (OTC) or by prescription, and the specific condition being treated.

Safe Dosage Guidelines

• Over-the-Counter Naproxen (e.g., Aleve):
  • Standard OTC naproxen tablets contain 220 mg of naproxen.
  • Adults should take one pill every 8 to 12 hours as needed.
  • Do not exceed 3 pills (660 mg) in 24 hours.
  • If pain is not relieved by one pill, two pills may be taken within the first hour, but no more than two pills in any 8 to 12-hour period

• Prescription-Strength Naproxen:
  • Available in 250 mg, 375 mg, and 500 mg tablets.
  • Typical recommended dose is 250 mg to 550 mg twice a day.
  • Maximum daily dose should not exceed 1,100 mg to 1,375 mg depending on the source.
  • For some acute conditions like gout attacks, an initial dose of 750 mg may be given, followed by 250 mg every 8 hours until relief

• Maximum Daily Limits:
  • For general use, do not exceed 1,000 mg per day (500 mg twice daily) is a common recommendation to avoid side effects.
  • Some sources allow up to 1,375 mg per day for short periods.
  • The NHS notes for painful periods, do not exceed 1,250 mg in 24 hours

Important Safety Notes

• Taking more than the recommended dose increases risks of gastrointestinal issues (like bleeding), kidney damage, and cardiovascular events such as heart attacks and strokes

• Naproxen interacts with blood thinners and some blood pressure medications, so consult a doctor if you are on such treatments

• Use the lowest effective dose for the shortest time possible to minimize risks

Summary

Formulation| Typical Dose| Max Daily Dose
---|---|---
OTC Naproxen (220 mg)| 220 mg every 8-12 hours| 660 mg (3 pills)
Prescription Naproxen| 250-550 mg twice daily| 1,100-1,375 mg
Painful Periods (NHS)| Up to 1,250 mg daily| 1,250 mg

Always follow package instructions or your doctor’s advice, and do not exceed recommended doses to avoid serious side effects