The maximum recommended daily dose of Tylenol (acetaminophen) for most healthy adults is 4,000 milligrams (mg). This includes all sources of acetaminophen combined. For some individuals, such as those with liver problems or who regularly consume alcohol, the safe maximum dose may be lower, often suggested at 2,000 mg per day or less. Typically, adults can take 650 mg to 1,000 mg per dose every 4 to 6 hours, without exceeding the total daily limit. It is also important to consider all medications taken to avoid accidental overdose. Always follow product labels or medical advice regarding dosing.