The safe maximum dose of Tylenol (acetaminophen) during pregnancy is generally 3,000 milligrams (mg) per day, divided into doses of 650 to 1,000 mg every 6 to 8 hours as needed. It is important not to exceed this limit because pregnancy reduces the body's ability to metabolize higher doses safely, and many combination medications contain hidden acetaminophen that should be accounted for to avoid overdose. Short-term use at this dosage is considered safe for mild pain and fever relief during all stages of pregnancy. If pain or fever persists beyond 72 hours, consult a healthcare provider. Avoid regular or long-term use without medical advice. This dosing guideline is supported by major health organizations such as the American College of Obstetricians and Gynecologists (ACOG) and recent medical reviews in 2024, which found no increased risk of autism or ADHD at recommended doses during pregnancy.