Extra Strength Tylenol (500 mg of acetaminophen per tablet) can typically be taken as 2 tablets every 6 hours while symptoms last. It is important not to exceed 6 tablets in 24 hours unless directed by a doctor, which corresponds to a maximum dose of 3,000 mg of acetaminophen per day. Taking more often or exceeding this dosage can risk serious liver damage. Always follow the package instructions or a healthcare provider’s advice, especially if there are liver conditions or other health concerns.