Naproxen can typically be taken every 6 to 12 hours depending on the condition being treated and the formulation used. For example, for pain and dysmenorrhea, the usual initial dose is 550 mg once, then 275 mg every 6 to 8 hours or 550 mg every 12 hours as needed, with a maximum of about 1375 mg per day initially and 1100 mg per day thereafter. For arthritis and long-term conditions, it is often taken twice daily, with doses ranging from 250 mg to 500 mg or 375 mg to 500 mg twice a day, not exceeding 1500 mg per day for limited times. Over-the-counter naproxen is usually taken 220 mg every 8 to 12 hours while symptoms persist, with a possible initial 440 mg dose if needed. It is important not to exceed the recommended daily dose and to take naproxen for the shortest time necessary to control symptoms to avoid side effects. For long-term use, doctors may prescribe stomach protection medication due to possible gastrointestinal risks. Specific dosing and frequency should be confirmed with a healthcare provider tailored to individual needs and conditions.