You can donate plasma as often as once every 6 to 7 days, typically up to twice per week, with at least one day between donations. This is because plasma regenerates quickly, usually within 24 to 48 hours, allowing more frequent donations than whole blood, which requires about 56 days between donations

. The U.S. FDA regulations allow plasma donation once every two days but no more than twice in a seven-day period, which aligns with the common practice of donating twice weekly with a day gap in between

. In other countries, donation frequency recommendations vary slightly:

• Canadian Blood Services allows plasma donation every 7 days

• Australian Lifeblood permits plasma donation as often as every 2 weeks

• UK and New Zealand guidelines often recommend plasma donation every 2 weeks, with blood donations spaced further apart

In summary, the typical maximum frequency for plasma donation is about twice per week, with at least one day between donations, but this can vary depending on local regulations and donor health considerations.