It is generally safe to take Tylenol (acetaminophen) soon after taking naproxen, as they belong to different drug classes and work differently in the body. A common practice is to take these medications about 3 hours apart to alternate their pain relief effects and reduce the risk of side effects. For example, if naproxen is taken, Tylenol can typically be taken after about 3 hours, depending on your pain control needs and dosages. Both medications have different elimination pathways (naproxen through kidneys and Tylenol through the liver), so taking them together or in close sequence is generally safe if dosages are within recommended limits. It is important not to exceed the recommended daily doses of either medication and to take naproxen with food to avoid stomach upset. If you plan to use both, alternating every 3 hours is commonly suggested, but always consult your healthcare provider if you have any underlying liver, kidney, or other health conditions or if pain persists beyond a couple of days.