To clean mattress stains effectively, follow these steps:

1. Act Quickly: Immediately blot the stain with a clean towel to absorb excess liquid without rubbing.
2. Use a Cleaning Solution: Depending on the stain, use mild solutions like a mix of water and white vinegar, baking soda paste, or dishwashing liquid diluted in water. For sick stains, an enzyme-based cleaner or a mix of equal parts water and white vinegar is effective.
3. Apply the Cleaner: Spray or dab the cleaning solution on the stain and let it sit for about 5-10 minutes.
4. Blot Again: Use a clean cloth to blot and remove the solution along with the stain.
5. Dry Thoroughly: Dry the mattress completely using a fan or open window to prevent mold without heat sources like hairdryers.
6. Vacuum Residue: Once dry, vacuum the mattress to pick up any leftover particles or baking soda.

For yellow stains, a solution of hydrogen peroxide, water, and dish soap can be used carefully, followed by baking soda application and brushing for stain removal. For tougher stains, repeated cleaning or a commercial stain remover may be necessary. Never saturate the mattress, and always blot rather than rub to avoid pushing stains deeper into the fibers.