To clean a night guard effectively:

1. Rinse the night guard with warm water immediately after use to remove saliva and debris.
2. Gently brush the night guard with a soft-bristled toothbrush using water or mild, alcohol-free soap; avoid abrasive toothpaste.
3. For a deeper clean once a week, soak the night guard in a solution of equal parts white vinegar and water for 15-30 minutes, then gently scrub with a toothbrush.
4. Rinse thoroughly with warm or cool water to remove any residue.
5. Allow the night guard to air dry completely on a clean surface before storing it in a ventilated case to prevent bacterial growth.
6. Avoid using hot water, bleach, alcohol, or abrasive cleaning agents, as they can damage the night guard.

Additional cleaning options include using denture cleaning tablets or a combination of hydrogen peroxide and vinegar for deep cleaning. Regular cleaning after each use and weekly deep cleaning help maintain the night guard's condition and hygiene effectively.