To clean On Cloud shoes effectively, hand-washing with mild detergent and a soft-bristle brush is recommended. Start by removing the laces and insoles, then brush off loose dirt and dried mud. Clean the shoes using a mixture of lukewarm water and gentle soap, scrubbing the uppers and outsoles carefully. Rinse with clean water to remove soap residue and air dry away from direct heat. Laces and insoles should be cleaned separately and dried before reinserting. Alternatively, specialized products like SneakERASERS offer an easy, quick cleaning solution that works well on different materials without damaging the shoes. Machine washing is possible only for fabric or mesh models, using a gentle cycle and a mesh laundry bag. Key tips include avoiding harsh chemicals, bleach, hot water, and direct heat for drying to protect your shoes' materials and structure.