To clean up your Gmail inbox efficiently, follow these key steps:

1. Use Gmail's search bar to filter unwanted emails by sender, keyword, attachment, size, or date. This helps identify bulk emails to delete.
2. Delete emails with large attachments or emails older than a certain period to free up space.
3. Organize your emails with labels and categories to easily filter notifications and other common types of messages.
4. Unsubscribe from newsletters and mailing lists you no longer want.
5. Block unwanted senders to prevent receiving future emails from them.
6. Regularly empty the Trash folder to permanently delete emails and free storage.
7. Consider using third-party tools like Clean Email which offer bulk actions and automation to speed up cleanup and maintain organization.

Breaking cleanup into manageable steps and using search filters is an effective way to declutter without missing important messages. Keeping your inbox organized with labels and automated rules helps maintain cleanliness long term.