The main cast of the 2003 romantic comedy film How to Lose a Guy in 10 Days includes:

• Kate Hudson as Andie Anderson
• Matthew McConaughey as Benjamin Barry
• Adam Goldberg as Tony
• Kathryn Hahn as Michelle
• Annie Parisse as Jeannie
• Thomas Lennon as Thayer
• Michael Michele as Judy Spears
• Shalom Harlow as Judy Green
• Robert Klein as Phillip Warren
• Bebe Neuwirth as Lana Jong

These are the principal actors who play key roles in the movie about a magazine writer and an advertising executive who both have hidden agendas in their relationship