The main cast (reparto) of the 2003 romantic comedy film How to Lose a Guy in 10 Days includes:

• Kate Hudson as Andie Anderson
• Matthew McConaughey as Benjamin "Ben" Barry
• Kathryn Hahn as Michelle Rubin
• Adam Goldberg as Tony
• Annie Parisse as Jeannie Ashcroft
• Thomas Lennon as Thayer

The film was directed by Donald Petrie and features a story about Andie, a magazine writer who tries to lose a guy in 10 days for an article, while Ben, an advertising executive, bets he can make a woman fall in love with him in the same period