Safe in Red Dead Redemption 2 can be opened most reliably by using dynamite to blow it open. Here’s a concise guide:

• Where to get dynamite: Purchase at gun stores or acquire from your gang camp after it’s upgraded enough. You can also find dynamite during various missions or at a Fence, depending on progress.

• How to use it on safes: Approach the safe, plant dynamite near it, then ignite the fuse and move away to a safe distance before it explodes. The explosion will blow the door off and reveal the contents inside.

• Alternative methods (less reliable): Some players have reported opening safes with throwing weapons like tomahawks or throwing knives if timed precisely, or using lantern/candle-based tricks seen in videos. However, these methods are not official or consistently reliable and may vary by patch. If you don’t have dynamite, these are potential but uncertain options you might encounter in guides or videos.

Tips to minimize risk:

• Always keep dynamite stock topped up so you’re prepared for safes you encounter on trains or in camps.

• Stand at a reasonable distance when igniting to avoid damage from the blast.

• Safes typically yield cash, valuables, or loot useful for fences or camp progression.

If you’d like, I can tailor these steps to your current game progress (which chapter you’re in, whether you’ve unlocked a Fence or upgraded the camp) and provide a quick checklist for a single playthrough.