To remove ink from clothes, the most effective methods involve using solvents like rubbing alcohol, hair spray (preferably alcohol-based), or hand sanitizer to dilute the stain. The general steps include:

1. Blot the excess ink gently with a paper towel, taking care not to spread the stain.
2. Test the solvent (rubbing alcohol, hair spray, or hand sanitizer) on an inconspicuous area of the fabric for colorfastness.
3. Place a paper towel under the stained area, then apply the solvent onto the stain to break down the ink.
4. Blot and rinse the area with cold water.
5. Pretreat the stain with a stain remover or detergent, gently rubbing it in with a soft toothbrush or by rubbing the fabric.
6. Wash the garment according to its care label, preferably at the hottest safe temperature.
7. Repeat the process if the stain persists before drying, as heat will set the stain.

Other household alternatives include using ammonia (for ballpoint or felt-tip ink), nail polish remover (acetone-based), or a baking soda paste for tough stains. Always avoid drying the clothes before fully removing the stain to prevent it from setting permanently.