There are many polite and natural ways to reply to "thank you." Common and effective responses include:

• "You're welcome." (classic and versatile)
• "Glad I could help."
• "My pleasure."
• "Anytime."
• "No problem" (informal, friendly)
• "Don't mention it."
• "Happy to do this for you."
• "I appreciate you saying that."
• "It was nothing."
• "Sure!" (informal)

The choice depends on context — formal or casual — and personal style. For professional settings, phrases like "You're welcome," "My pleasure," or "Happy to help" are often best, while informal replies such as "No worries" or "Sure thing" suit casual situations well. Using these responses can express gratitude, humility, and willingness to help again, making conversations more pleasant and natural.