Adapalene is a topical retinoid with FDA approval for treating acne vulgaris. It is a third-generation retinoid that is more chemically stable than retinol. Adapalene works by promoting cell turnover, which prompts older skin cells to die and come off, making room for newer skin cells to reveal themselves. It also prevents comedones, or clogged pores, which makes it a great acne-fighting agent.

Adapalene is not a retinol, but rather a type of retinoid, which is a vitamin A derivative. Retinol is mainly used for anti-aging, while adapalene has an indication for acne in addition to anti-aging benefits. Adapalene is a less irritating alternative to harsher retinoids, without compromising effectiveness.

Some positive aspects of adapalene include its high efficacy in treating acne vulgaris with fewer side effects. It is also available over-the-counter, making it more accessible to people who need it. However, some negative aspects of adapalene include that it can still be pretty irritating, especially during the first few weeks of use. Adapalene also increases sensitivity to the sun by thinning the stratum corneum, so it is important to follow up with a sunscreen.

The active ingredient in Differin Gel, which is an adapalene product, is adapalene 0.1% (retinoid) . The inactive ingredients include carbomer 940, edetate disodium, methylparaben, poloxamer 182, propylene glycol, purified water, and sodium hydroxide.