The chords for the song "Is He Worthy" commonly start in the key of D or E depending on the version. Here is a general outline of the chords used in the song:

• Verses typically use chords like D, Bm, G, F#m.
• The chorus includes chords such as G, A, Bm, and variations like F#m.
• Some versions also use chords in the key of E like E, C#m, A, G#m, B.
• The progression generally follows a worship style pattern emphasizing chords for melody and accompaniment.

For example, one common progression from the verses and chorus is: Verse:
| D | Bm | G | D | F#m | G | D | Chorus:
| G | A | Bm | A | G | A | Bm | A | F#m | G | This corresponds to lines like "Is anyone worthy, is anyone able to break the seal and open the scroll?" Different arrangements may use capo or slightly different keys (like C capo 2) but maintain this basic chord structure. The chords create a flowing and worshipful sound suitable for acoustic and band performance.

If desired, specific chord fingerings and a full chord sheet can be provided.