There is no single definitive "cure" for Lyme disease, but it is usually effectively treated and often cured with appropriate antibiotic therapy, especially when diagnosed early. The standard treatment involves a 10-14 day course of antibiotics such as doxycycline, amoxicillin, or cefuroxime, which typically results in rapid and complete recovery for most patients. However, 10-20% of patients may not fully respond to standard treatment, and some experience post-treatment symptoms that are not caused by active infection. New research from Northwestern University suggests that the antibiotic piperacillin, at a much lower dose than doxycycline, can effectively cure Lyme disease in experimental models and may cause fewer side effects. This antibiotic targets the Lyme bacteria's unique biology and is less disruptive to gut bacteria. However, it is not yet approved specifically for Lyme disease treatment in humans. Other emerging treatments, such as Hygromycin A and various alternative therapies, are under investigation but lack conclusive evidence. Early diagnosis and treatment remain crucial for best outcomes, and ongoing research aims to improve treatment options, especially for patients with persistent symptoms after antibiotic therapy. No approved human vaccine is currently available for Lyme disease prevention. In summary, Lyme disease can be effectively cured with antibiotics if treated early, but research continues to refine and improve treatment options for resistant or persistent cases.