Wegovy (semaglutide) is generally considered safe and effective for long-term use under medical supervision, especially for adults with obesity or overweight and related health issues. Clinical trials and studies show that severe side effects are rare but possible, including pancreatitis, gallbladder disease, kidney damage, and potential thyroid tumors. The most common side effects are gastrointestinal—such as nausea, vomiting, diarrhea, constipation, and fatigue—which often occur early in treatment and tend to lessen over time. Regular medical monitoring is recommended to manage side effects and assess continued use effectiveness and safety.

Wegovy has received FDA approval based on clinical trials demonstrating effectiveness and safety over periods up to about 16 months, with ongoing studies to evaluate long-term risks. It is not safe for people with certain thyroid cancers or digestive conditions, and it is contraindicated in pregnant or breastfeeding women. For most people who tolerate it well, continuing treatment is often advised to maintain weight loss because stopping the medication typically leads to weight regain.

In summary, while Wegovy is safe for many people when taken as directed, it requires medical supervision to monitor for potential serious side effects and to ensure appropriate use based on individual health conditions.