Urea cream is a topical medication used to treat hyperkeratotic conditions such as dry, rough skin, dermatitis, psoriasis, xerosis, ichthyosis, eczema, and keratosis. It contains urea as an active ingredient, which is a diamide of carbonic acid. Urea is a natural moisturizing factor (NMF) that helps the skin hold onto water and keep it plump, elastic, and hydrated. Urea cream also contains other inactive ingredients such as ceteareth-6, ceteareth-25, cetyl alcohol, mineral oil, carbomer, dimethyl isosorbide, glyceryl stearate, petrolatum, propylene glycol, purified water, sodium hydroxide, and xanthan gum.

Positive experiences with urea cream have been reported by 71% of reviewers. Urea cream is effective in treating skin disorders connected to excessive dryness and malfunctioning skin barrier. However, some negative side effects may occur, such as skin irritation, redness, and itching.