Based on the search results, "What a shame Mary Jane" can refer to different things:

• YouTube channel: "What a shame Mary Jane" is the name of a YouTube channel run by a person who adopts a philosophical approach to life.
• Instagram account: "What a shame Mary Jane" is also the name of an Instagram account run by a digital nomad based in NYC and Friuli.
• Pronunciation course: "What a shame Mary Jane" is the name of a course that helps fix common pronunciation mistakes.
• Song: "Whats the shame Mary Jane" is a song that was a common effort of Syd Barrett, John Lennon, and Yoko Ono. There are different versions of the song, some featuring Lennons voice and others featuring Syds voice.

It is unclear if there is any connection between these different uses of the phrase "What a shame Mary Jane."