Barbiturates are a class of drugs that are central nervous system depressants. They reduce the activity of nerves causing muscle relaxation, and can reduce heart rate, breathing, and blood pressure. Barbiturates affect gamma-aminobutyric acid (GABA), a neurotransmitter that nerves use to communicate with one another. They are used to treat a wide range of conditions, including anxiety, insomnia, seizures, migraines, and preoperative anxiety. Some common barbiturates include Fiorina®, Pentothal®, Seconal®, Nembutal®, amobarbital (Amytal), and butabarbital (Butisol) .

Barbiturates can be abused by swallowing a pill or injecting a liquid form. They are generally abused to reduce anxiety, decrease inhibitions, and treat unwanted effects of illicit drugs. Barbiturates can cause mild euphoria, lack of restraint, relief of anxiety, impairment of memory, judgment, and coordination, irritability, paranoia, and suicidal ideation. Overdose effects of barbiturates include central nervous system depression, decreased respiration, increased heart rate, decreased blood pressure, decreased urine production, decreased body temperature, coma, and possible death.

It is important to note that barbiturates are controlled substances and can be habit-forming. They can also interact with other medications, so it is important to inform your doctor of all medications you are currently taking.