"What are little girls made of?" is a line from a nursery rhyme that dates back to the 19th century. The rhyme goes as follows:

What are little girls made of? What are little girls made of? Sugar and spice, And everything nice, Thats what little girls are made of.

The rhyme expresses the idea that little girls are sweet and gentle, made up of pleasant things like sugar and spice, while little boys are made up of rougher things like snips and snails and puppy dogs tails. However, it is important to note that this is just a nursery rhyme and does not reflect the true nature of boys and girls.

It is worth mentioning that "What Are Little Girls Made Of?" is also the title of an episode of the American science fiction television series, Star Trek. In this episode, Nurse Chapel searches for her long lost fiancé and uncovers his secret plan to create sophisticated androids for galactic conquest.

In recent years, there have been several reworkings of the nursery rhyme that aim to challenge traditional gender roles and stereotypes. For example, Jeanne Willis wrote a book called "What Are Little Girls Made Of?" that rewrites the rhyme with a feminist twist. In her version, little girls are made of "sun and rain and heart and brain".