During pregnancy, many over-the-counter (OTC) cold medicines can be taken safely, but it is crucial to consult your healthcare provider before use and follow package directions carefully. Here are commonly recommended options: Safe Cold Medicines in Pregnancy:

• Acetaminophen (Tylenol): Safe throughout pregnancy for pain and fever relief; avoid if allergic or if you have liver problems

• Dextromethorphan: A cough suppressant found in products like Robitussin; considered safe with a maximum dose of 120 mg per 24 hours

• Guaifenesin: An expectorant that helps loosen mucus; generally safe in the second and third trimesters but should be avoided in the first trimester

• Chlorpheniramine and Diphenhydramine: Antihistamines used for allergy symptoms and sneezing; considered safe but may cause drowsiness

• Pseudoephedrine (Sudafed): Safe only in the second and third trimesters; avoid in the first trimester due to a small risk of birth defects and if you have high blood pressure or heart disease

• Nasal sprays: Saline sprays and oxymetazoline (Afrin) can be used for short-term relief of nasal congestion, but oxymetazoline should not be used for more than three days to avoid rebound congestion

• Cetirizine (Zyrtec) and Loratadine (Claritin): Safe antihistamines with less drowsiness, used for allergy-related symptoms

Medications to Avoid:

• Ibuprofen, naproxen, aspirin (NSAIDs), especially in the third trimester

• Combination multi-symptom cold medicines like DayQuil, NyQuil, or Mucinex FastMax, as they may contain unsafe ingredients

• Codeine-containing cough medicines are generally not recommended due to limited effectiveness and potential risks

Additional Advice:

• Use medications only as needed and for the shortest duration possible.
• Avoid unnecessary medications; treat only the symptoms you have.
• Non-medication remedies such as honey for cough (a spoonful of real honey) can be a safe alternative

• Seek medical attention if you have a high fever (above 102°F), thick yellow-green mucus, chest pain, wheezing, or symptoms that worsen or last more than a few days

In summary, acetaminophen, certain antihistamines, dextromethorphan, guaifenesin (after the first trimester), and some nasal sprays are generally safe options during pregnancy, but always check with your healthcare provider before taking any medication