The color of plasma can vary considerably from one sample to another, ranging from barely yellow to dark yellow, and sometimes with a brown, orange, or green tinge. The normal color of plasma is yellow due to the presence of bilirubin, carotenoids, hemoglobin, and transferrin. However, in abnormal cases, plasma can have varying shades of orange, green, or brown. Green color can be due to ceruloplasmin or sulfhemoglobin, while reddish-orange plasma is usually caused by red blood cells that have ruptured and decomposed, which is a process known as hemolysis. Smokers are more prone to having reddish-orange plasma due to the contaminated lack of oxygen in their system. Milky white and cloudy plasma can also occur. In summary, the color of plasma can vary depending on the presence of different pigments and the occurrence of hemolysis or other abnormalities.