Powerball numbers are drawn three times a week, on Mondays, Wednesdays, and Saturdays. The drawings take place at 10:59 pm ET on Mondays, Wednesdays, and Saturdays, and at 7:59 pm PT on Mondays, Wednesdays, and Saturdays. Its important to note that sales cut-off times vary by one to two hours before the drawing, depending on the location.