According to the search results, the Mega Millions drawings are held every Tuesday and Friday. The drawings are held at 8:00 p.m. on Tuesdays and Fridays in California, at 11:00 p.m. ET on Tuesdays and Fridays in most states, and at 10:45 p.m. in Ohio. The cut-off time for purchasing a Mega Millions ticket is 9:59 p.m. on the drawing days.