D'Angelo died from pancreatic cancer on October 14, 2025, after a prolonged and courageous battle with the disease. He was 51 years old at the time of his death. The singer's family confirmed the cause of death and shared that he had been in hospice care for two weeks and hospitalized for several months prior. His son was by his side during his final days. D'Angelo had kept his diagnosis private and did not publicly disclose his illness before passing away.