Piers Morgan has been one of Meghan Markle's most outspoken critics, making numerous public remarks questioning her credibility and criticizing her actions. He infamously declared he did not believe Meghan Markle's statements during her Oprah interview, especially regarding her mental health struggles and allegations of racism within the royal family, saying, "I wouldn't believe Meghan Markle if she read me a weather report" and calling her narrative "disingenuous" and "disgraceful". Morgan has repeatedly accused her of exaggerating or fabricating claims, stating that “seventeen claims made by Meghan and Harry have now been proven false, exaggerated, or unprovable” and described the onslaught against the royal family as “contemptible”.

He has also mocked her Netflix series, criticized her for continuing to use her duchess title, and argued that her public persona is the result of a "cynical and manipulative PR campaign". Morgan's contentious relationship with Meghan partly stems from a perceived personal snub after she reportedly cut off their friendship, a point he has referenced publicly on several occasions.

Morgan’s repeated criticisms have led to widespread public debate and even his dramatic exit from Good Morning Britain after refusing to apologize for his remarks, following confrontation about his ongoing attacks on Meghan. While he insists he is exercising free speech and holding Meghan accountable, others see his comments as overly personal and sometimes fueled by a grudge.