Ulcerogenic refers to the property of causing ulcers, which are painful sores or lesions that develop on the lining of the stomach or the small intestine. This term is often used in the context of certain drugs, especially anti- inflammatory medications, that can induce ulcers as a side effect

. Ulcerogenic agents cause ulcers primarily by damaging or irritating the mucous lining that protects the stomach and intestinal walls from digestive acids. For example, nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen and aspirin are ulcerogenic because they inhibit prostaglandin synthesis, which normally helps maintain the protective mucus layer and blood flow in the stomach lining. This disruption leads to inflammation and erosion, resulting in ulcers

. The most common causes of ulcers include infection with the bacterium Helicobacter pylori and prolonged use of NSAIDs. H. pylori infection causes chronic inflammation of the stomach lining, weakening its defenses and leading to ulcer formation. NSAIDs cause irritation and reduce the stomach’s ability to repair itself, increasing ulcer risk

. In summary, ulcerogenic causes lead to the development of ulcers by damaging the protective mucous lining of the digestive tract, either through bacterial infection (H. pylori) or chemical irritation and inhibition of protective factors (NSAIDs and other ulcerogenic drugs)