Ozempic is not indicated for weight loss, but it may be prescribed off-label for this use. The starting dose of Ozempic is usually 0.25 mg injected once weekly for the first 4 weeks, and then the dose is increased to 0.5 mg once weekly for at least 4 weeks. After that, the dose may be increased every 4 weeks up to 2 mg once weekly, depending on how the patient responds to the medication. In general, its best to take the lowest effective dose. The healthcare provider will guide patients along a once-weekly dosing schedule to find the right Ozempic dosage. The maximum dose of Ozempic is 2 mg once a week.