Lisa Renée Irwin, a 10-month-old infant, disappeared from her home in Kansas City, Missouri, in the early morning hours of October 4, 2011. According to Lisas mother, Deborah Bradley, Lisas father, Jeremy Irwin, discovered her missing around 4:00 a.m. on Tuesday, October 4, 2011. Lisa had been in her bed when Deborah checked on her at 6:40 p.m. or at 10:40 p.m. Monday night, but when Jeremy came home from his late-night job on Tuesday, he discovered "many of the homes lights were on, a window was open, and the front door was unlocked". Later, the family told police that several cellphones were also missing.

Despite extensive searches and investigations, Lisa has not been found, and her disappearance remains a cold case. Her case has been featured on various media platforms, including the podcast The Vanished and the HLN series Real Life Nightmare. Her parents still hold out hope for her return, ten years after her disappearance.