Brock Purdy, the San Francisco 49ers' starting quarterback, suffered a toe injury described as a variant of turf toe along with a left shoulder issue during the team's Week 1 victory over the Seattle Seahawks in the 2025 NFL season. Due to this injury, he was ruled out for the Week 2 game against the New Orleans Saints and is expected to be sidelined for multiple weeks, with an anticipated recovery time of about 2 to 5 weeks. The 49ers are not optimistic about Purdy returning in the immediate future, including the Week 3 home game against the Arizona Cardinals, though there remains a slim chance if his recovery progresses well. The team is currently managing his situation as a week-to-week case and is closely monitoring his progress. In Purdy's absence, backup quarterback Mac Jones is starting for the 49ers. Purdy had signed a significant five-year, $265 million contract extension before the season began, making this injury a notable setback for both him and the team. Overall, Purdy is recovering but has not yet returned to play as of mid- September 2025, with cautious hopes for his return in the near future depending on his rehabilitation progress.