Karen Jackson is a character from the TV show Shameless. She is a complex and controversial figure due to her troubled family background, and she often uses her sexuality for manipulation and control. Here is what happened to Karen in the show:

• Karen miraculously survives a car crash, but she is hospitalized with severe injuries and placed in a medically induced coma).
• After obtaining brain damage due to being run over by Mandy, Karen moves to Arizona with Jody and her baby in order to recover.
• Karen undergoes a significant transformation, displaying a calmer and seemingly happier demeanor, shedding her previous selfish personality.
• Karens exit from the show is tragic, but her character had naturally reached its conclusion in the show.

In summary, Karen survives a car crash but suffers brain damage after being run over by Mandy. She moves to Arizona with Jody and her baby to recover, and her character exits the show in a poignant departure.