Karlie Gusé disappeared on October 13, 2018, from Bishop, California, after exhibiting paranoia and unusual behavior following marijuana use, which her family suspected might have been laced with another substance. She left her home early that morning and was last seen walking near Highway 6 and Sierra View Road. Despite extensive searches by the Mono County Sheriff's Office and the FBI, no confirmed trace of Karlie has been found, and she has not contacted family or friends since her disappearance

. There are two main theories about what happened to Karlie: one suggests she wandered into the desert and died from exposure, as the area is harsh and dangerous; the other theory is that she got into a vehicle, willingly or forcibly, and was taken elsewhere. The lack of evidence or leads has made the case particularly challenging, with authorities noting "the biggest clue is that there is no clue"

. In the years since, there have been unconfirmed reports of sightings, including one in Tonopah, Nevada, which is near the area where her scent was last lost by tracking dogs. This has kept hopes alive that she might still be found, but the FBI and local law enforcement continue to seek information to solve the mystery

. Karlie's family has not given up hope, and her 20th birthday was marked by the release of an age-progressed image to aid in the search. Her case remains open and is the subject of ongoing investigations and media coverage

. In summary, Karlie Gusé remains missing since 2018 under mysterious circumstances, with no definitive conclusion about her fate. The investigation continues, with the possibility of either accidental death in the desert or abduction still considered