Marvin Harrison Jr. has been dealing with a medical issue that caused him to miss games in 2025. Specifically, he underwent appendicitis surgery and was ruled out for Week 11, with ongoing uncertainty about his return timeline beyond that game. He was widely reported as missing Week 11 against the San Francisco 49ers due to the appendectomy, and updates through mid‑November suggested a possible return in Week 12, though nothing was officially confirmed at that time. His absence marked the first time in his NFL career he missed a game due to injury or surgery, and the Cardinals adjusted their receiving corps accordingly while he recovered. [sources from November 2025 reporting include NFL.com/ESPN-style outlets; see detailed coverage during that period]