Yes, it is possible to overdose on antidepressants, especially if taken with other drugs or medications. Overdosing on prescription antidepressant medication is possible if a person takes too many of their or someone else’s pills. Taking a higher dose of antidepressants than directed by a doctor can flood the system with more drugs than it can metabolize, leading to toxicity or overdose. Symptoms of an antidepressant overdose may include nausea, vomiting, and blurred vision. In severe cases, overdose may be life-threatening, and symptoms may include hallucinations, seizures, tremors, low blood pressure, coma, cardiac arrest, respiratory depression, and death. The lethal dosage of an antidepressant depends on many factors, including the type of antidepressant, how the body metabolizes the medication, weight, age, and preexisting conditions. If someone suspects an antidepressant overdose, they should call 911 immediately.