When you stop taking Ozempic, your full appetite may return within a week, increasing your calorie intake and leading to weight regain. Ozempic can also slow down gastric emptying, making you feel full for a longer period of time and decreasing your calorie intake, leading to weight loss. Therefore, when you stop taking Ozempic, your blood sugar levels may spike, worsening the effects of type 2 diabetes on your blood vessels, which can lead to eye, heart, and nerve disease. In addition, the medication can cause side effects like nausea, vomiting, diarrhea, stomach pain, or constipation, which may go away over time when you stop taking it. However, some people may experience mild headaches or upset stomachs while on semaglutide, and ending the medication can be a relief for them. The effects of stopping Ozempic or Wegovy may be noticed after a week or so, and many people will gain weight after weeks or months without the medication. If you are considering stopping Ozempic, it is important to contact your doctor before doing so, as they may recommend transitioning to another treatment or reducing your dose to help with possible side effects.