Restless legs syndrome (RLS) can be a contributory factor in sleep disturbances in cancer patients undergoing chemotherapy00403-4/fulltext). Here are some measures that can help relieve RLS symptoms during chemotherapy:

• Medications: Ropinirole is a medication that significantly improves RLS symptoms within one week of treatment and also has a beneficial effect on sleep disturbances and quality of life. Gabapentin and pregabalin are also sometimes prescribed to help relieve painful symptoms of RLS.

• Screening for iron deficiency: A ferritin level <75µg/L is a good indicator of low iron stores and warrants iron supplementation. The blood work should also include renal function and a screen for diabetes with HgA1C, B12, and folate deficiency.

• Avoiding offending medications: Medications that can worsen RLS are tricyclics (TCA), selective serotonin reuptake inhibitors (SSRI), lithium, antipsychotics, dopamine antagonists, antihistamines, and antiemetics.

• Hot or cold baths: Hot or cold baths can be beneficial.

• Leg massages: Leg massages can help relieve RLS symptoms.

• Relaxation exercises: Relaxation exercises, such as yoga or tai chi, can help relieve RLS symptoms.

• Gentle exercise: Mild exercise, such as walking and stretching, can be beneficial. However, strenuous exercise should be avoided since it can worsen RLS symptoms.

It is important to discuss any RLS symptoms with a healthcare professional to determine the best course of treatment.