Devin Booker began playing high school basketball at Grandville High School in Michigan. However, after his freshman year, he moved to Mississippi to live with his father, who was hired as an assistant coach at Moss Point High School. Booker played for the freshman, junior varsity, and varsity basketball teams during his freshman year at Grandville High School. He played most of his high school basketball at Moss Point High School, where he led the team to the state title in his senior year. Bookers success at Moss Point High School earned him a scholarship to the University of Kentucky.