A fracture dislocation of the ankle is a severe injury that occurs when there is an abnormal separation between the bones of the ankle joint, and one or more of the bones in the ankle cracks or breaks. This type of injury is more severe than a simple ankle sprain and often occurs concomitantly with an ankle fracture due to the strength of the surrounding stabilizing ligaments in the ankle. The most common resulting fractures are bimalleolar and trimalleolar, which often result from an abduction force and displacement of the talus. Symptoms of a fracture dislocation of the ankle include severe pain, swelling, bruising, misaligned foot or ankle, numbness to the impacted area, loss of use of the injured area, and muscle spasms around the injured area. Treatment for a fracture dislocation of the ankle may include anti-inflammatory medicines, a cast or walking boot, surgery, and physical therapy. The outcome and complication rate after a fracture dislocation of the ankle is multifactorial, and factors that can influence a patient’s outcome include the mechanism of injury, fracture type, open fractures, and medical comorbidities.