Acute propofol intoxication is a condition that occurs when a person takes too much propofol, leading to severe side effects and, in some cases, death. Propofol is a drug that is commonly used as an anesthetic to induce loss of consciousness during surgery or other medical procedures. It is also used for conscious sedation of patients undergoing procedures on an outpatient basis at surgery centers. Propofol is administered intravenously and has a short duration of action and rapid clearance.

In the case of Michael Jackson, the Los Angeles County coroner concluded that he died from acute propofol intoxication, which caused him to stop breathing. Jacksons personal physician, Dr. Conrad Murray, reportedly administered propofol infusions to Jackson for two months as a sleep-aid, causing him to abstain from rapid eye movement (REM) sleep.

Propofol is not meant to be used as a sleep aid or outside of a clinical setting by anesthesiologists. The initial administration of propofol can cause pain at the injection site, and administering toxic doses can harm a patients overall condition. Propofol infusion syndrome (PRIS) is the manifestation of propofol toxicity, which can lead to changes in blood pressure and heart rate at higher doses.

In summary, acute propofol intoxication is a condition that occurs when a person takes too much propofol, leading to severe side effects and, in some cases, death. Propofol is a drug that is commonly used as an anesthetic to induce loss of consciousness during surgery or other medical procedures. It is not meant to be used as a sleep aid or outside of a clinical setting by anesthesiologists.