Alpha-lipoic acid (ALA) is a naturally occurring compound that is made in the body and serves vital functions at the cellular level, such as energy production. ALA is an antioxidant that protects against damage to the bodys cells. There are food sources of ALA such as yeast, organ meats like liver and heart, spinach, broccoli, and potatoes, but ALA from food does not appear to produce a noticeable increase in the level of free ALA in the body. Some people take ALA supplements with the intent to improve a variety of health conditions, such as diabetes, neuropathy, and ischemic-perfusion injury. However, scientific evidence for the health benefit of supplemental ALA has been inconclusive.

Studies have suggested that ALA supplements may enhance the bodys ability to use its own insulin to lower blood sugar in people with diabetes. ALA has the strongest evidence of its therapeutic effect in diabetic neuropathy and oxidative stress conditions. According to the FDA, ALA is reported to be safe and effective, and there are promising uses that can be explored in future studies.

ALA is considered a safe supplement that can be purchased over the counter, and a daily dose of 200 to 2400 mg/day of ALA is deemed safe without side effects. However, ALA should not be used without a recommendation from a doctor if you take insulin or other medications to lower blood sugar, as its possible that it can enhance the effect of these drugs, leading to hypoglycemia (low blood sugar) . Because of the potential for side effects and interactions with medications, you should take dietary supplements only under the supervision of a health care provider.